VDR is a gene that encodes for a protein which functions as a receptor for vitamin D which regulates bone growth and calcium absorption. A variant of the gene (rs2228570, FokI polymorphism) is associated with a decreased bone mineral density among prepubescent girls of white background.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern and temporal off-and-on occupancy of the VDRE between the two components. It is also controlled by chromosomal position and binding preferences for certain hormones. Microarray studies of human cells have revealed that more than 100 genes contain a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) can serve as a repository of data and documents that are relevant to business, legal transactions or proceedings. Viewing, downloading, and printing are all restricted. It uses a central server as well as an extranet connection, which is an Internet connection with restricted access to allow restricted access to log-in for specific times at which users can access the data and documents.
VDRs are primarily used by investment banks and companies involved in mergers and acquisitions. They must be able to communicate information in a clear way with potential investors or buyers. Due diligence will also require a significant amount of data. Life science companies also utilize VDRs to store everything from clinical trials results to HIPAA documentation.